Vimovo is a prescription medication used to treat the pain and inflammation associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It is also used to prevent ulcers. It comes as a single tablet containing 2 medications, esomeprazole and naproxen. Esomeprazole belongs to a group of drugs called proton pump inhibitors which work by reducing acid production in the stomach. Naproxen is a nonsteroidal antiinflammatory drug NSAID that works by blocking the production of substances that cause inflammation. Vimovo is taken twice daily, at least 30 minutes before a meal. Swallow tablets whole.